Dr James Lester is a research associate who works on a number of topics within clinical informatics, including hepatitis C treatment, system development for managing researcher data use, and surgical site infection. His work on hepatitis C is a particular focus, investigating treatment outcomes in the context of the recent introduction of directly acting antivirals (DAAs), especially in the case of non-optimal treatment compliance. Whilst DAAs have the potential to offer extremely effective treatment, those at greatest risk of infection, people who inject drugs, remain difficult to reach and retain in treatment. As such, he is interested in the rates at which different groups uptake, complete, and are cured by treatment, as well as the rates at which these groups develop serious disease, with the goal of providing an overview of the balance between disease progression and effective treatment targeting in the DAA era.
James’s PhD thesis concerned the epidemiology of disease within wildlife and human populations at the edge of Kibale National Park in Western Uganda. This work included field work to implement a real-time electronic disease surveillance system within the human population living alongside the park, and detailed phylogenetic and behavioural analysis of patterns of viral infection within wild red colobus monkeys.
Lester JS, Paige S, Chapman CA, Gibson M, Holland Jones J, Switzer WM, Ting N, Goldberg TL, Frost SD. Assessing Commitment and Reporting Fidelity to a Text Message-Based Participatory Surveillance in Rural Western Uganda. PLoS One. 2016 Jun 9;11(6):e0155971. doi: 10.1371/journal.pone.0155971. eCollection 2016.
Brayne AB, Dearlove BL, Lester JS, Kosakovsky Pond SL, Frost SD. Genotype-Specific Evolution of Hepatitis E Virus. J Virol. 2017 Apr 13;91(9). pii: e02241-16. doi: 10.1128/JVI.02241-16
Schmidt F, Liegeois F, Greenwood EJ, LeBreton M, Lester JS, Deleplancque L, Peeters M, Aghokeng A, Tamoufe U, Diffo JL, Takuo JM, Wolfe ND, Leroy E, Rouet F, Heeney JL. Phyloepidemiological Analysis Reveals that Viral Divergence Led to the Paucity of Simian Immunodeficiency Virus SIVmus/gsn/mon Infections in Wild Populations. J Virol. 2017 Feb 28;91(6). pii: e01884-16. doi: 10.1128/JVI.01884-16